Pregnenolone

Description

Pregnenolone is an endogenous Steroid Hormone (also described as a Neurosteroid or Steroid Neurohormone) 

Aging & Life Extension

 Pregnenolone production in humans declines markedly in tandem with the progression of the Aging Process and supplemental Pregnenolone may help to counteract various aspects of the Aging Process:  ^[1]

 A 75 year old person produces approximately 60% less Pregnenolone compared to the average person aged 35.

 A 90 year old person produces approximately 95% less Pregnenolone compared to the average person aged 30.

 Pregnenolone may possess Life Extension potential.  ^[2]

Ears/Hearing

 Pregnenolone may improve Hearing ability.  ^[3]

Eyes/Vision

 Pregnenolone concentrates in and is produced in the Retina.  ^[4]

 Pregnenolone may improve Sight (according to anecdotal reports describing and improvement in the clarity of vision after using supplemental Pregnenolone)  ^[5]

Immune System

 Pregnenolone may help to prevent some forms of Cancer. 

 Pregnenolone may improve some aspects of the Immune System.  ^[6]

 Pregnenolone may suppress Inflammation.  ^[7]

 Pregnenolone (50 - 600 mg per day) may be of some benefit to Lupus Erythematosus patients.  ^[8]

Metabolism

 Pregnenolone may rejuvenate the Beta Cells of the Pancreas in Diabetes Mellitus Type 1 patients. 

 Pregnenolone may improve subjective feelings of Energy.  ^[9]

 Supplemental Pregnenolone may help to prevent Fatigue.  ^[10]

 Pregnenolone is reported to rapidly resolve the protrusion of the Eyes (Exophthalmia) associated with Grave's Disease: 

 This claim is made on the basis of a physician’s report of a female Graves Disease patient whose Exophthalmia receded within 24 hours of Pregnenolone administration.

 Supplemental Pregnenolone may cause weight loss in persons afflicted with Obesity (according to preliminary reports). 

 Supplemental Pregnenolone may improve Stamina (especially in people affected by excessive Stress). 

Musculoskeletal System

 Pregnenolone may help to lower elevated total serum Cholesterol levels.  ^[11]

 Pregnenolone (50 - 100 mg per day) may be of some benefit to Osteoarthritis patients.  ^[12]

 Pregnenolone may be useful for the treatment of Osteoporosis (due to its conversion to Progesterone within the body).  ^[13]

 Supplemental Pregnenolone (500 mg per day) was developed originally as a treatment for Rheumatoid Arthritis:  ^[14]

 Pregnenolone may be most effective against Rheumatoid Arthritis during the early stages of the disease, before the inflammatory processes has manifested in full.

 Pregnenolone (50 - 100 mg per day) may be of some benefit to Scleroderma patients.  ^[15]

Nervous System:  Ailments

 Alzheimer's Disease patients and patients with other forms of Dementia often have abnormally low levels of Pregnenolone.  ^[16]

 Pregnenolone may be useful for the treatment of Anxiety:  ^[17]

 It has been speculated that supplemental Pregnenolone may be useful for the treatment of Obsessive-Compulsive Disorder.  ^[18]

 It has been speculated that supplemental Pregnenolone may be useful for the treatment of Panic Disorder.  ^[19]

 Pregnenolone may help to alleviate Depression (especially where Depression is caused by excessive Cortisol):  ^[20]

 Pregnenolone is speculated to be useful for the treatment of Manic Depression (during both the Manic and Depression phases).  ^[21]

 Pregnenolone may be an effective treatment for Multiple Sclerosis (MS).  ^[22]

 Pregnenolone is presently under investigation as a means of preventing or reversing Paralysis in people who have sustained Spinal Cord injuries.  ^[23]

 Pregnenolone (30 mg per day) may alleviate Schizophrenia.  ^[24]

 Pregnenolone (50 - 100 mg per day) may improve the body’s ability to handle Stress:  ^[25]

 Pregnenolone down-regulates the binding of Glucocorticoids to Glucocorticoid Receptors (a process involved in Stress).

Nervous System:  Enhancement

 Pregnenolone may increase Alertness.  ^[26]

 Pregnenolone may improve (hand-to-eye) Coordination.  ^[27]

 Pregnenolone may increase Creativity.  ^[28]

 Pregnenolone may increase Intelligence.  ^[29]

 Pregnenolone may improve Learning ability.  ^[30]

 Pregnenolone may improve Memory.  ^[31]  The means by which Pregnenolone improves Memory include:

 Maintaining the “program” that Neurons require in order to store and retrieve Memory.

 By stimulating the endogenous enzyme Adenyl Cyclase.