Tumor Necrosis Factor

Also known as:  TNF;  Tumour Necrosis Factor

Tumor Necrosis Factor is an endogenous Cytokine produced by various Cells (including Macrophages and Monocytes).

Immune System

 TNF stimulates the proliferation of B-Lymphocytes.

 TNF diminishes the supply of Blood and Oxygen to the tumors that are involved in various forms of Cancer:  ^[1]

 Endogenous TNF possesses anti- properties:  it damages the Blood Vessels that nourish tumors.  This damage to the Blood Vessels reduces the supply of Blood and Oxygen to tumors and causes them to bleed into themselves and die.

 TNF reduces the production of Free Radicals by Cancer cells.

 Exogenous TNF further enhances the ability of Hyperthermia to successfully treat some forms of Cancer.

 If high concentrations of TNF-alpha are released into the body for extended periods of time, TNF-alpha loses its ability to fight Cancer.

 TNF (both TNF-alpha and TNF-beta forms) inhibits the replication of Viruses.  ^[2]

Hormones

 TNF (TNF-a form) increases the production of Corticotropin-Releasing Hormone (CRH) by the Hypothalamus.  ^[3]

Heat Therapy

 Exogenous TNF further enhances the ability of Hyperthermia to successfully treat some forms of Cancer.  ^[4]

Carbohydrates

 Acemannan may stimulate the production of TNF-Alpha by Macrophages.  ^[5]

 Echinacin may stimulate Macrophages to release TNF-Alpha.  ^[6]

 Grifolan (a form of Beta 1,3 Glucan present in Maitake Mushrooms) stimulates the production and activity of TNF-Alpha by Macrophages.  ^[7]

 Lentinan may enhance the ability of exogenous, genetically-engineered TNF to destroy Cancer cells: 

 Lentinan may also stimulate the endogenous production of TNF in Cancer patients.

Carotenoids

 Beta-Carotene may increase the production of TNF-alpha. 

Cytokines

 Interferon Gamma may enhance the ability of Tumor Necrosis Factor to destroy Cancer cells.  ^[8]

 Interleukin 1 (IL-1) may stimulate the activity of Tumor Necrosis Factor.  ^[9]

Electromagnetic Radiation

 UV-Bexposure may increase the production of Tumor Necrosis Factor.  ^[10]

Enzymes

 Bromelain (especially when administered in conjunction with Pancreatic Amylase and Papain) may increase the production of Tumor Necrosis Factor (TNF-alpha form).  ^[11]

 Pancreatic Amylase (especially when administered in conjunction with Bromelain and Papain) may increase the production of Tumor Necrosis Factor (TNF-alpha form).  ^[12]

 Papain (especially when administered in conjunction with Bromelain and Pancreatic Amylase) may increase the production of Tumor Necrosis Factor (TNF-alpha form).  ^[13]

 When exogenous Superoxide Dismutase (SOD) is administered prior to or concurrently with exogenous TNF in the treatment of Cancer, the survival rates of patients increases by up to 79% - SOD may counteract the toxicity of TNF without interfering with TNF and, in fact, may enhance the effectiveness of TNF.  ^[14]

Algae

 Hijiki may facilitate the release of the TNF-alpha form of TNF from Macrophages.  ^[15]

Herbs

 Astragalus may increase the body’s production of TNF.  ^[16]

 Black Cumin (seeds) may increase the body’s production of TNF (TNF-alpha form).  ^[17]

 Echinacea may increase the body’s TNF levels (due to the Echinacin content of Echinacea).  ^[18]

 Sanchi Ginseng may stimulate the body’s production of the TNF (TNF-alpha form) (due to Polysaccharides in Sanchi Ginseng).  ^[19]

Mushrooms

 Maitake Mushrooms may stimulate the production and activity of TNF-alpha by Macrophages (due to the Grifolan content of Maitake).  ^[20]