Depression - Major

Major Depression is described as Recurrent Unipolar Depression when it occurs repeatedly over the course of months or years.

Amino Acids

 5-HTP (5-Hydroxytryptophan) may alleviate Major Depression.  ^[1]

 Acetyl-L-Carnitine (ALC) may be effective for the treatment of Major Depression (especially when Major Depression affects the elderly).  ^[2]

 Many Major Depression patients are found to have low levels of Aspartic Acid (and supplemental Aspartic Acid may therefore be beneficial for Major Depression patients).  ^[3]

 Creatine Monohydrate may alleviate Major Depression.  ^[4]

 S-Adenosylmethionine (SAMe) may alleviate Major Depression.  ^[5]

 Tryptophan may alleviate some cases of Major Depression.  ^[6]

 Tyrosine (6,000 mg per day for at least two weeks) may alleviate some cases of Major Depression.  ^[7]

Hormones

 DHEA (Dehydroepiandrosterone) may alleviate Major Depression.  ^[8]

 Testosterone replacement therapy may alleviate Major Depression (especially in men who have insufficient endogenous production of Testosterone).  ^[9]

 Thyroid Hormones (especially Triiodothyronine (T3), used in conjunction with Pharmaceutical Antidepressants) may alleviate Major Depression:  ^[10]

 Triiodothyronine (T3) (used in conjunction with Pharmaceutical Antidepressants) may alleviate Major Depression.  ^[11]

Lipids

 Major Depression patients are often found to have sub-optimal levels of Omega-3 Fatty Acids:  ^[12]

 Docosahexaenoic Acid (DHA) may alleviate Major Depression.  ^[13]

 Eicosapentaenoic Acid (EPA) may alleviate Major Depression.  ^[14]

Minerals

 Chromium may alleviate Major Depression.  ^[15]

 Lithium (150 mg per day of the Lithium Orotate form of Lithium) may alleviate (recurrent) Major Depression.  ^[16]

 Magnesium may be useful for the treatment of Major Depression (as Major Depression patients have been found to have abnormally low serum Magnesium levels).  ^[17]

 Zinc may improve Mood in Major Depression patients (especially when supplemental Zinc is used in conjunction with Pharmaceutical Antidepressants).  ^[18]

Prescribed Medications

 Dopamine Reuptake Inhibitors may be an effective treatment for many cases of Major Depression:

 Amineptine may alleviate many cases of Major Depression.  ^[19]