S-Adenosylmethionine

Description

S-Adenosylmethionine, SAMe, is the active Lipotrope form of Methionine, normally manufactured within the body from the essential amino acid methionine and adenosine triphosphate, ATP, an energy-producing molecule found in all cells in the body.

Digestive System

 Supplemental SAMe may stimulate the flow of Bile. 

 Supplemental SAMe (600 - 800 mg per day) may help to prevent Cholestasis (by improving the flow of Bile).  ^[1]

Immune System

 Acquired Immune Deficiency Syndrome (AIDS) patients have low endogenous Cerebrospinal Fluid (CSF) levels of SAMe and for this reason supplemental SAMe is under investigation as a potential treatment for AIDS.  ^[2]

 SAMe may help to prevent Cancer - Colon.  ^[3]

 Supplemental SAMe may help to protect against Cancer - Liver in people exposed to Liver carcinogens.  ^[4]

 SAMe may inhibit the growth of Cancer - Stomach cells.  ^[5]

Metabolism

 Supplemental SAMe (1,200 mg per day) may significantly reduce the elevated Bilirubin levels that are associated with Gilbert's Syndrome.  ^[6]

 SAMe may help to protect Liver cells and may help to preserve Liver cell function in Hepatitis C patients.  ^[7]

 SAMe is stored in the Liver and supplemental SAMe may enhance the health of the Liver and normalize the function of the Liver:  ^[8]

 SAMe may help to prevent the Liver toxicity associated with the Prescribed Medications used in Chemotherapy.

 Supplemental SAMe may inhibit Alcohol-induced Liver damage (including Alcohol-induced Fatty Liver).

 Supplemental SAMe may prevent and cure Cirrhosis.  ^[9]

 Supplemental SAMe may prevent and treat Fatty Liver.  ^[10]

 SAMe functions in over forty biochemical reactions within the body - it functions as a .

Musculoskeletal System

 SAMe may stimulate the production of Cartilage.  ^[11]

 Supplemental SAMe may enhance the differentiation of Chondrocytes into Chondroblasts.  ^[12]

 Supplemental SAMe (800 mg per day) may alleviate Fibromyalgia:  ^[13]

 Specific improvements in Fibromyalgia symptoms caused by SAMe therapy include a significant reduction in the number of trigger points, reduction in Fatigue, reduction in morning stiffness and improvements in Mood.

 Supplemental SAMe (400 - 1,200 mg per day) alleviates Osteoarthritis (by increasing Cartilage formation).  ^[14]

 Supplemental SAMe may alleviate Fibrositis. 

Nervous System

 Alzheimer's Disease patients often exhibit severely decreased levels of SAMe within their Brains (indicating that supplemental SAMe may be beneficial to Alzheimer’s Disease patients):  ^[15]

 It was previously (prior to 1995) assumed that Alzheimer’s Disease patients had excessive accumulation of SAMe - this assumption has now proven to be erroneous.