Indole-3-Carbinol

Description

Indole-3-Carbinol is a type of Indole.  Chemically, it is a metabolite of Glucobrassicin, which in turn is a hydrolytic product of Glucosinolates.

Immune System

 Indole-3-Carbinol may prevent and suppress the progression of some forms of Cancer:  ^[1]

 Indole-3-Carbinol may suppress those forms of Cancer that are initiated by Papilloma Viruses (by modulating Estrogen metabolism).  ^[2]

 Indole-3-Carbinol may help to prevent some forms of Cancer by facilitating the binding of various carcinogens to Glucuronic Acid to form Glucuronides.

 Indole-3-Carbinol may reduce the ability of Heterocyclic Aromatic Amines (HAAs) (e.g. PhlP) to initiate Cancer and may reduce the ability of HAAs to damage the body’s endogenous Deoxyribonucleic Acid (DNA).  ^[3]

 Indole-3-Carbinol may maintain the integrity of the p53 Tumor Suppressor Gene (a Gene that helps to prevent Cancer).  ^[4]

 Indole-3-Carbinol may help to prevent Cancer - Breast by stimulating the conversion of Estrone (the Estrogen which is known to cause Breast Cancer in excess) to its metabolite 2-Hydroxyestrone (an inactive metabolite).  ^[5]

 Indole-3-Carbinol may help to Prevent Cancer - Cervix especially Papilloma Virus (HPV-16)-initiated Cervical Cancer.  ^[6]

 The principal underlying mechanism for the ability of Indole-3-Carbinol to prevent Cervical Cancer involves the ability of Indole-3-Carbinol to inhibit the ability of Papilloma Virus 16 to stimulate the conversion of Estrone to 16-Hydroxyestrone, a byproduct of Estrone that is a known initiator of Cervical Cancer.

 Indole-3-Carbinol may counteract the ability of many dietary carcinogens to initiate Cancer - Colon.  ^[7]

 Indole-3-Carbinol may inhbit the development of Cancer - Endometrium.  ^[8]

 Indole-3-Carbinol may help to prevent Leukemia.  ^[9]

 Indole-3-Carbinol may help to prevent Cancer - Liver:  ^[10]

 Indole-3-Carbinol may inhibit the ability of Aflatoxin to cause Liver Cancer.  ^[11]