Fibrinogen
Also known as: Factor I
Description
Fibrinogen is a type of Globulin (soluble Protein).
Biological Function of Fibrinogen
Cardiovascular System
Fibrinogen is involved in the process of Blood Clotting (Blood Coagulation):
Thrombin reacts with Fibrinogen (in the presence of ionized Calcium) to form Fibrin. [1]
Toxic Effects of Excessive Fibrinogen Production
Cardiovascular System
Excessive Fibrinogen levels may cause unwarranted Blood Clotting (due to excessive Platelet aggregation induced by Fibrinogen). [2]
Excessive Fibrinogen levels are a causative factor for many Cardiovascular Diseases: [3]
Elevated Fibrinogen levels are associated with an increased risk of Hypertension. [4]
Excessive Fibrinogen levels may increase the risk of Ischemic Heart Disease (e.g. Heart Attack and Angina). [5]
Excessive Fibrinogen levels may increase the risk of Stroke. [6]
Elevated Fibrinogen levels may increase the risk of Thrombosis. [7]
Skin
If excessive Inflammation occurs during the healing of Wounds, large quantities of Fibrinogen coagulate in the Scar Tissue associated with Wounds and this Fibrinogen subsequently contributes to post-healing Scarring.
These Substances may Lower Elevated Fibrinogen Levels
The controlled inhibition of Fibrinogen is desirable in that it inhibits the formation of undesirable Blood Clotting.
Amino Acids
Arginine may lower Fibrinogen levels (it may stimulate fibrinolysis) by stimulating Plasmin (an enzyme that catalyzes the conversion of Fibrin to more soluble metabolites). [8]
Enzymes
Bromelain may stimulate fibrinolysis (the breakdown of Fibrinogen). [9]
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