Alpha-Ketoglutarate

Alpha-Ketoglutarate is a type of Alpha-Keto Acid.

Metabolism

 Alpha-Ketoglutarate may improve Athletic Performance (by increasing and by increasing the production of Energy).  ^[1]

 Alpha-Ketoglutarate may help to prevent and reverse Cachexia (i.e. muscle wasting syndrome) by increasing Muscle Glutamine stores. 

 Alpha-Ketoglutarate (Pyridoxine Alpha-Ketoglutarate (PAK) form - 1,800 mg per day) may enhance the effectiveness of Insulin and Phenformin in Diabetes Mellitus patients (both Diabetes Mellitus Type 1 and Diabetes Mellitus Type 2). 

 Alpha Ketoglutarate is an intermediate chemical in the body''s Krebs Cycle of endogenous Energy production:  ^[2]

       View Alpha Ketoglutarate''s Role in the Krebs Cycle 

Musculoskeletal System

 Supplemental AKG may improve the integrity of the Connective Tissue and Ligaments of children afflicted with Down''s Syndrome (by enhancing the production of Collagen).  ^[3]

 Alpha-Ketoglutarate is speculated to enhance Muscle Growth: 

 This speculation is based on studies that show that Alpha-Ketoglutarate can reverse Muscle wasting (Cachexia) in hospital patients by increasing Glutamine stores within the Muscles.