Nitrosamines
Description
Nitrosamines are a toxic group of Amines. They are organic oxides of Nitrogen that are formed within the body when Nitrites and Nitrates react with Amino Acids.
Toxic Effects of Nitrosamines
Immune System
Nitrosamines are extremely potent carcinogens which can cause Cancer in any part of the body including: [1]
Esophagus Cancer [2]
Gliomas [3]
Larynx Cancer [4]
Liver Cancer
Lung Cancer
Mouth Cancer
Stomach Cancer [5]
Metabolism
Nitrosamines may cause Liver damage.
These Foods Contribute to the Formation of Nitrosamines
These Foods contribute to Nitrosamine formation due to their Nitrate or Nitrite content.
These Substances Cause the Formation of Nitrosamines within the Body
Food Preservatives
Nitrates are converted in the Stomach to Nitrosamines.
Nitrites are converted in the Stomach to Nitrosamines.
Recreational Drugs
The Nitrate ions generated by Amyl Nitrate (inhalation) may increase the body's production of Nitrosamines.
These Substances may Counteract Nitrosamines
Amino Acids
Alpha-Ketoglutarate (AKG) may inhibit the ability of Nitrosamines to cause Liver Cancer. [6]
Thioproline may prevent the conversion of dietary Nitrites to Nitrosamines.
Carbohydrates
Nitrosamines are excreted from the body as conjugates with Glucuronic Acid - these conjugates are known as Glucuronides and this process is known as glucuronidation.
Enzymes
Nitrate Reductase detoxifies Nitrates, preventing their conversion to Nitrosamines.
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