Osteoclasts
Description
Osteoclasts are a specialized type of Osteocyte (Bone Cell) formed from Hematopoietic Stem Cells.
Biological Function of Osteoclasts
Musculoskeletal System
Osteoclasts continually travel through Bone tissue seeking "old" Bone that has become mineralized and in need of renewal. Osteoclasts then dissolve these mineralized tissues leaving unfilled spaces (lacunae) behind - for "filling" by Osteoblasts.
These Substances may Suppress Osteoclasts
Amino Acids
Arginine may stimulate the production of Nitric Oxide, a Neurotransmitter that inhibits the Bone-resorption activity of Osteoclasts. [1]
Carotenoids
Lycopene may inhibit the formation of Osteoclasts. [2]
Enzymes
Superoxide Dismutase (SOD) may inhibit the generation of Superoxide Free Radicals that cause the activation of Osteoclasts. [3]
Hormones
Calcitonin may inhibit the activities of Osteoclasts.
DHEA (Dehydroepiandrosterone) may inhibit the activities of Osteoclasts.
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