Insulin - Substances/Factors that Enhance

These Substances may Enhance the Function of, or Influence the Production of Insulin

Alkaloids

 Long-term use of Ephedrine may reduce Insulin Resistance (i.e. it increases the sensitivity of Insulin Receptors to the effects of Insulin).

Amino Acids

 Arginine may increase Insulin production. 

 Cystine may enhance the supply of Insulin to the Pancreas - Cystine comprises 12% of the Insulin molecule. 

 Glutamine may stimulate the production of Insulin. 

 Glycine may stimulate the secretion of Insulin. 

 Ketoisocaproate (KIC) may stimulate the secretion of Insulin from the Pancreas and may stimulate the uptake of Insulin into Muscle tissue.  ^[1]

 Leucine may stimulate the secretion of Insulin from the Pancreas and may stimulate the uptake of Insulin into Muscle tissue.  ^[2]

 Ornithine Alpha-Ketoglutarate (OKG) (10,000 mg per day) may stimulate the release of Insulin.  ^[3]

 Phenylalanine is a precursor for the production of Insulin.

 Taurine may potentiate the effects of Insulin.  ^[4]

Growth Factors

 Insulin-like Growth Factor-1 (IGF-1) inhibits the ability of Insulin to transport Glucose across Cell Membranes (thereby forcing the body to mobilize Fatty Acids from Adipose Tissue as an alternative means of maintaining endogenous Energy production).  ^[5]

Hormones

 Adrenaline may decrease the release of Insulin.

 DHEA (Dehydroepiandrosterone) may increase the effectiveness of Insulin, may lower the body’s requirement for exogenous Insulin in Diabetes Mellitus patients and may inhibit (detrimental) age-related increases in Insulin production/release.  ^[6]

 Gastric Inhibitory Peptide stimulates the release of Insulin as part of the process of digestion.

 Neuropeptide Y stimulates the secretion of Insulin (caution:  excessive secretion of production of Neuropeptide Y can cause dangerously high levels of Insulin).

Lipids

 Beta-Sitosterol may help to normalize Insulin levels in Diabetes Mellitus Type 2 patients.  ^[7]

 Conjugated Linoleic Acid (CLA) may help to normalize Insulin levels.  ^[8]

 Prostaglandin E1 (PGE1) may inhibit the secretion of excessive quantities of Insulin from the Beta Cells of the Pancreas and may normalize Insulin sensitivity.  ^[9]