Methotrexate

Also known as:  Amethopterin;  Amethopterine;  Antifolan;  Ledertrexate;  Metatrexan;  Methopterin;  Methyl-aminoopterin;  Methylaminopterin

Brand Names:  Emtexate;  Maxtrex;  Methoblastin;  Rheumatrex

Methotrexate is a type of Antimetabolite Anti-Cancer Pharmaceutical Drug.

Digestive System

 Methotrexate (administered via weekly injection) may increase the chance of remission in Crohn's Disease patients.  ^[1]

Immune System

 Methotrexate is commonly employed in the treatment of various forms of Cancer (it works by preventing the conversion of Folic Acid to its active Folinic Acid form - Folinic Acid is essential for the endogenous production of Deoxyribonucleic Acid (DNA) - DNA is required for the reproduction of Cancer cells, so by preventing DNA production, new Cancer cell growth is also prevented):

 Methotrexate (administered intravenously in high doses) is commonly utilized in the treatment of Cancer - Bone.

 Methotrexate (administered intravenously in high doses) is commonly utilized in the treatment of Cancer - Breast.

 Methotrexate (administered intravenously in high doses) is commonly utilized in the treatment of Leukemia.

 Methotrexate (administered intravenously in high doses) is commonly utilized in the treatment of Lymphomas.

 Methotrexate (administered intravenously in high doses) is commonly utilized in the treatment of Cancer - Cervix.

 Methotrexate (administered intravenously in high doses) is commonly utilized in the treatment of Cancer - Lung.

 Methotrexate is occasionally used in the treatment of severe cases of Systemic Lupus Erythematosus (SLE).

Musculoskeletal System

 Methotrexate is sometimes used in the treatment of Rheumatoid Arthritis (however many physicians are reluctant to use Methotrexate for this purpose because of the toxic side effects associated with Methotrexate).

Skin

 Methotrexate (administered orally in low doses) is commonly utilized in the treatment of Psoriasis (however Methotrexate is reserved only for severe cases of Psoriasis due to its toxic side effects).  ^[2]