5'-Deiodinase

2 min readEvidence-linked topicGreen Medicine Encyclopedia

Description

5'-Deiodinase is a type of Deiodinase enzyme.

 

Function of 5'-Deiodinase

Hormones

 5'-Deiodinase catalyzes the conversion of Thyroxine (T4) to Triiodothyronine (T3) in peripheral tissues.  Under normal physiological conditions, approximately 30% of Thyroxine is converted by this enzyme to Triiodothyronine.

 5'-Deiodinase catalyzes the conversion of Reverse T3 (reverse T3)to 3,3'-Dioodothyronine (3,3'-T2) in peripheral tissues.

 

Metabolism

 Increasing 5'-Deiodinase activity is useful for Euthyroid Sick Syndrome patients (due to its role in the production of Triiodothyronine from Thyroxine).

 

These Substances may Enhance the Function of 5'-Deiodinase

Minerals

 Selenium (in the form of Selenocysteine) is a cofactor for 5'-Deiodinase (Type I).  [1]

 

Vitamins

 Vitamin C may inhibit the ability of Cadmium to reduce the activity of 5'-Deiodinase (the enzyme that catalyzes the conversion of Thyroxine to Triiodothyronine).  [2]

Keep reading 5'-Deiodinase

  • These Substances may Impair the Function of 5'-Deiodinase
  • Hormones
  • Minerals
  • Prescribed Medications
  • These Herbs may Inhibit the Activity of 5'-Deiodinase
  • Impaired 5'-Deiodinase Activity may be Asociated with these Ailments
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