IgE

Also known as:  Epsilon Globulin;  Immunoglobulin E

IgE is a type of Antibody (an Immunoglobulin) that is present in only miniscule amounts in the Blood Plasma.

Immune System

 IgE is produced within the body in response to Antigens (including Allergens) by specialized B-Lymphocytes known as IgE Plasma Cells.

 IgE binds to Antigens and this combined compound is then attracted to Basophils (in the bloodstream) or Mast Cells (in connective tissues) that then "burst" and release their stored Histamine and Serotonin as a defense mechanism against these Antigens:

 IgE is a unique type of Immunoglobulin in that it binds not to just one specific Antigen (like other Immunoglobulins) but can bind with a large number of potentially dangerous Antigens.

 IgE plays a role in the prevention of infestations from Intestinal Parasites.

Immune System

 Elevated IgE levels (which are often inherited) may be implicated in Allergies:  ^[1]

 IgE can bind (cross-link with) to many different Antigens and can “decide” which foreign substances to treat as Antigens (e.g. in some persons it “decides” that Pollen is an Antigen and reacts as such).