Matrix Metalloproteinases

Also known as:  Matrix Metallopeptidases;  Matrixins;  MMP

Matrix Metalloproteinases are a group of Endogenous Proteolytic Enzymes.  They are produced by Fibroblasts.

Skin

 Matrix Metalloproteinases break down the Extracellular Matrix of the Skin during periods of Inflammation:  ^[1]

 The break down of the Extracellular Matrix of the Skin by Matrix Metalloproteinases is desirable and necessary during the healing of Wounds as it facilitates Skin remodelling.

 The break down of the Extracellular Matrix of the Skin by Matrix Metalloproteinases is undesirable when the Extracellular Matrix of normal, healthy Skin is being broken down.

 Matrix Metalloproteinases are involved in reducing Scarring (they are involved in the breakdown of Scar tissue).

 Matrix Metalloproteinases “digest” damaged Collagen in the Skin, resulting in the reduction of Wrinkles.

Proteins

 Matrix Metalloproteinases (primarily Collagenase) break down and digest damaged Collagen in the Extracellular Matrix of the Skin.