Amyloid-Beta-Protein Precursor
Description
Amyloid beta-protein precursor, APP, produces the amyloid beta-protein an essential part of senile plaques and a cytotoxic fragment involved in the pathogenesis of Alzheimer disease. [1]
Potentially Toxic Effects of Amyloid beta-protein precursor
Nervous System
Mutations in the APP Gene account for 5% to 20% of early-onset Alzheimer's Disease. [2]
APP Is a Precursor for these Toxic Substances
Proteins
APP is the immediate precursor for Amyloid-Beta Protein (ABP). [3]
These Substances may Enhance the Function of APP
Cytokines
Interleukin 1 (IL-1) is involved in the promotion of Genes for APP.
Enzymes
Beta-Secretase (a Proteolytic Enzyme) (particularly the Beta-Secretase 1 form) catalyzes the conversion of APP to Amyloid-Beta Protein (ABP) - note that if the alternative enzyme, Alpha-Secretase acts on APP, no ABP is produced: [4]
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