5-Alpha Reductase

5-Alpha Reductase is a type of endogenous Oxidoreductase Enzyme manufactured in the Prostate, Adrenal Glands and the Scalp.

Hormones

 5-Alpha Reductase catalyzes the conversion of Testosterone to Dihydrotestosterone (DHT):  ^[1]

 Approximately 6 - 10% of the body’s Testosterone is converted to DHT.

 5-Alpha Reductase catalyzes the conversion of Androstenedione to 5-Alpha Androstenedione (5AA).

View the Metabolic Pathway for 5-Alpha Reductase

Prescribed Medications

 5-Alpha Reductase catalyzes the conversion of Nandrolone Decanoate to its “dihydro” form, Dihydronandrolone.

Hair

 5-Alpha Reductase is present in the Dermal Papilla (where it may contribute to Male Pattern Baldness).  ^[2]

 5-Alpha Reductase may be implicated in Hirsutism.

 5-Alpha Reductase may be implicated in Male Pattern Baldness (due to its role as a catalyst for the conversion of Testosterone to Dihydrotestosterone).  ^[3]

Immune System

 Excessive 5-Alpha Reductase levels or activity may be implicated in Prostate Cancer.

Sexual System (Male)

 5-Alpha Reductase may be implicated in Enlarged Prostate (due to its role as a catalyst for the conversion of Testosterone to Dihydrotestosterone - excessive serum Dihydrotestosterone is strongly implicated as a cause of Enlarged Prostate).