Phosphodiesterases

1 min readEvidence-linked topicGreen Medicine Encyclopedia

Also known as:  Phosphodiester Hydrolases

 

Description

Phosphodiesterases are a group of Esterases (enzymes).

 

Biological Function of Phosphodiesterases

 Phosphodiesterases hydrolyze cyclic Nucleotides (such as Cyclic AMP (cAMP) and Cyclic GMP(cGMP)).

 Phosphodiesterases act on Smooth Muscle tissues (such as those in arterial walls) and prevent them from relaxing (dilating).

 

These Substances may Inhibit Phosphodiesterases

Alkaloids

 Methylxanthines may inhibit the activity of some types of Phosphodiesterases: 

 Caffeine may inhibit the activity of some types of Phosphodiesterases. 

 

Types of Phosphodiesterases

 Phosphodiesterase-1

 Phosphodiesterase-2

 Phosphodiesterase-3

 Phosphodiesterase-4

 Phosphodiesterase-5

 

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