Acetylcholinesterase

Overview

Acetylcholinesterase is the most common type of Cholinesterase Esterase Hydrolase Enzyme present in the Synaptic Cleft of Neurons - Acetylcholinesterase is manufactured by the Liver.

Nervous System

 Acetylcholinesterase breaks (hydrolyzes) Acetylcholine down into its constituents - Choline (which is subsequently utilized in the production of fresh Acetylcholine) and Acetic Acid - so that subsequent Nerve Impulses can pass.

Alkaloids

 Capsaicin may inhibit the activity of Acetylcholinesterase.  ^[1]

 Chacocine may inhibit the production of Acetylcholinesterase. 

 Chaconine may inhibit the production of Acetylcholinesterase. 

 Huperzine A may inhibit Acetylcholinesterase:  ^[2]

 Clinical studies have determined that Huperzine A is a more effective Cholinesterase Inhibitor than the drugs Aricept, Galanthamine and Tacrine.

 Huperzine A is highly specific for Brain Acetylcholinesterase (it [desirably] has little effect on Acetylcholinesterase in other regions of the body).

 Huperzine A has a longer duration of action than other Cholinesterase Inhibitors.

 Solanine may inhibit the production of Acetylcholinesterase. 

Prescribed Medications

 Cholinesterase Inhibitors inhibit the production and activity of Acetylcholinesterase:

 Aricept potently inhibits the Acetylcholinesterase (Ache) enzyme - Aricept (unlike most other AChE Inhibitors) appears to be selective for central (rather than peripheral) AChE.