6-Hydroxydopamine
Description
6-Hydroxydopamine is a toxic metabolite of Dopamine (a Neurotoxin).
Toxic Effects of 6-Hydroxydopamine
Metabolism
6-OHDA may interfere with the body’s production of Energy (due to 6-OHDA causing depletion of Complex I in the Mitochondria). [1]
Nervous System
6-OHDA (after its uptake into Dopamine Receptors) may further auto-oxidize into toxic Free Radicals that damage Dopamine Receptors.
6-OHDA may impair Learning ability.
6-OHDA may impair Memory.
In addition to damaging Dopaminergic Neurons and Dopamine Receptors, 6-Hydroxydopamine may also damage other types of Neurons. [2]
6-OHDA (after gaining uptake into Dopamine Receptors) has been implicated in Parkinson's Disease. [3]
6-OHDA may cause massive lesions in the Substantia Nigra region of the Brain.
6-OHDA may Interfere with these Substances
Enzymes
6-OHDA may cause depletion of Complex I (an enzyme in the Mitochondria that is integral to the production of Energy by the Electron Transport System). [4]
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