Peroxynitrite Free Radicals

3 min readEvidence-linked topicGreen Medicine Encyclopedia

Also known as:  ONOO-

 

Description

Peroxynitrite Free Radicals are a type of Free Radical.

 

Sources of Peroxynitrite Free Radicals

Amino Acids

 Homocysteine may stimulate the generation of Peroxynitrite Free Radicals.  [1]

 

Exercise

 Exercise may increase the generation of Peroxynitrite Free Radicals.  [2]

 

Gases

 Excessive production of Nitric Oxide may generate Peroxynitrite Free Radicals.  This occurs from Nitric Oxide reacting with Superoxide Free Radicals to form Peroxynitrite Free Radicals.  [3]

 

Recreational Drugs

 Methamphetamine may stimulate the generation of Peroxynitrite Free Radicals in the Brain.  [4]

 Peroxynitrite Free Radicals are present in Tobacco smoke.

 

Toxic Effects of Peroxynitrite Free Radicals

Nervous System

 Alzheimer’s Disease patients generate large numbers of Peroxynitrite Free Radicals and these Peroxynitrite Free Radicals may contribute to the progression of Alzheimer’s Disease.  [5]

 Excessive generation of Peroxynitrite Free Radicals may be involved in Amyotrophic Lateral Sclerosis (ALS).  [6]

 Peroxynitrite Free Radicals may be implicated in Multiple Sclerosis. 

 Peroxynitrite Free Radicals may damage the Brain’s Neurons.

 

Peroxynitrite Free Radicals may Interfere with these Substances

Proteins

 Peroxynitrite Free Radicals may damage (induce the carbonylation of) the body’s Endogenous Proteins.

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