Cholic Acid
Overview
Cholic Acid is a type of Bile Acid formed from Cholesterol in the Liver. Cholic Acid is the second most abundant Bile Acid in human Bile, comprising 31% of Bile.
Biological Function of Cholic Acid
Digestive System
Cholic Acid is one of the various components of Bile.
Cholic Acid is a component of Sodium Taurocholate.
These Substances may Enhance the Function of Cholic Acid
Amino Acids
Taurine combines with Cholic Acid and Sodium to form the Bile Salt - Sodium Taurocholate (and may thereby prevent the toxic effects associated with excessive immobile Cholic Acid).
Enzymes
Cholesterol 7-Alpha-Monooxygenase catalyzes the conversion of Cholesterol to 7-Alpha-Hydroxycholesterol which, after various intermediate steps is eventually converted to Cholic Acid (and Chenodeoxycholic Acid). Cholesterol 7-Alpha-Monooxygenase is the rate-limiting enzyme for the production of Cholic Acid (and Chenodeoxycholic Acid).
Toxic Effects of Cholic Acid
Immune System
Excessive immobile Cholic Acid may cause Colon Cancer: [1]
- If the body's Colon transit time is slow and Bile is permitted to stagnate in the Colon, Detrimental Bacteria will convert Cholic Acid into the powerful carcinogen - Apcholic Acid.
Forms of Cholic Acid
Taurocholic Acid
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