5-HT3 Antagonists

1 min readEvidence-linked topicGreen Medicine Encyclopedia

Description

5-HT3 Antagonists are a group of Smart Drugs.

 

Therapeutic Uses of 5-HT3 Antagonists

Digestive System

 5-HT3 Antagonists alleviate (Diarrhea-predominant) Irritable Bowel Syndrome.

 5-HT3 Antagonists help to prevent Vomiting (by inhibiting the activation of 5-HT3 Receptors).

 

Nervous System

 5-HT3 Antagonists alleviate Nausea (by blocking 5-HT3 Receptors).

 

Mechanism of Action

 5-HT3 Antagonists bind specifically to 5-HT3 Receptors (a specific sub-type of Serotonin Receptor) (but not other types of 5-HT Receptors), thereby blocking their ability to receive Serotonin (consequently preventing Serotonin from inhibiting the release of Acetylcholine).

 

Types of 5-HT3 Antagonists

 Cilansetron

 Granisetron

 Ondansetron

 Tropisetron

 Zatosetron

 

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