Ornithine Decarboxylase
Also known as: ODC
Description
Ornithine Decarboxylase is a type of Decarboxylase Lyase Enzyme.
Biological Function of Ornithine Decarboxylase
Polyamines
Ornithine Decarboxylase catalyzes the endogenous synthesis of Polyamines: [1]
Ornithine Decarboxylase catalyzes the conversion of Ornithine to Putrescine.
Toxic Effects of Excessive Ornithine Decarboxylase Activity
Immune System
Excessive Ornithine Decarboxylase activity may be implicated in the development of some forms of Cancer (due to Ornithine Decarboxylase’s involvement in Cell proliferation) including: [2]
Bladder Cancer
Breast Cancer
Cervix Cancer
Colon Cancer
Lung Cancer
Prostate Cancer
Skin Cancer [3]
Musculoskeletal System
Excessive Ornithine Decarboxylase activity may be implicated in the onset of Psoriasis. [4]
Excessive Ornithine Decarboxylase activity may be implicated in excessive Wrinkles (this is believed to occur as a result of excess Ornithine Decarboxylase up-regulating the endogenous synthesis of Polyamines in the Skin, thereby disrupting normal Skin ). [5]
These Substances may Enhance the Function of Ornithine Decarboxylase
Lipids
Prostaglandin E2 (PGE2) may stimulate Ornithine Decarboxylase activity. [6]
Vitamins
Pyridoxal-5-Phosphate (the active endogenous coenzyme form of Vitamin B6) is an essential cofactor for Ornithine Decarboxylase.
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- Amino Acids
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