Cholecystokinin
Also known as: CCK; Pancreozymin
Description
Cholecystokinin is a Hormone produced in the wall of the Duodenum of the Small Intestine when food (especially dietary Fats) enters.
Biological Functions of Cholecystokinin
Digestive System
CCK stimulates Gallbladder contractions that discharge Bile into the Small Intestine.
CCK stimulates the secretion of Pancreatic Juice from the Pancreas.
Metabolism
CCK may help to prevent Obesity (by suppressing Appetite):
Animals afflicted with Obesity are less sensitive to the Appetite-suppressant effects of CCK than non-obese animals.
Nervous System
CCK sends Appetite suppressing messages to the Brain: [1]
CCK affects the quantity of food consumed at meals. As food accumulates in the Stomach and upper Small Intestines, CCK is released, influencing the Satiety Center of the Hypothalamus (causing Satiety or suppressed Appetite).
Three mechanisms have been proposed for CCK’s Appetite suppressant effects:
CCK binds to its receptor on the Gastric Pylorus, causing contraction resulting in Stomach distention. This Stomach distention activates receptors on the Afferent Gastric Vagus Nerve which then transmits signals via the Nucleus Tratus Solarius (NTS) to the Satiety Center of the Hypothalamus.
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