Cyclodextrins
Also known as: Cellulosine; Schardinger Sugars
Description
Cyclodextrins are a group of Dextrins. They are “sleeves” of Dextrin.
Uses of Cyclodextrins [1]
Delivery Vehicle
Cyclodextrins are used as penetration enhancing agents. They increase the sublingual absorption of compounds that are administered sublingually. Cyclodextrins embrace small lipophilic molecules, “smuggling” them into solution in watery fluid. By “hiding” the lipophilic molecule, Water is “tricked” into permitting the lipophilic substance into solution, where it can then disperse throughout the mouth. When the Cyclodextrin-lipophilic complex reaches a lipid-based area or structure (for example the Oral Mucosal membranes), the lipophilic substance slides out of its “sleeve” (Cyclodextrin) and penetrates the cell. The complex of a Cyclodextrin and a lipophilic substance is known as a Sublingual Cyclodextrin Complex (SCC). Substances that are often mixed with Cyclodextrins in order to improve their sublingual bioavailability include:
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