Lipoxygenase
Description
Lipoxygenase, LOX, is a group of Fatty Acid Metabolizing Enzymes.
Biological Function of Lipoxygenase
Eicosanoids
Lipoxygenase catalyzes the conversion of Arachidonic Acid to Series 4 Leukotrienes:
View Lipoxygenase's Participation in the Production of Series 4 Leukotrienes
Lipoxygenase catalyzes the conversion of Arachidonic Acid (AA) to s of Lipoxins:
View the Metabolic Pathway for Lipoxins
Toxic Effects of Lipoxygenase
Immune System
Lipoxygenase catalyzes the production of Series 4 Leukotrienes that are involved in the Inflammation process. [1]
Excessive activity of 5-Lipoxygenase stimulates the proliferation of Prostate Cancer cells. [2]
Metabolism
Excessive activity of 12-Lipoxygenase may be involved in Diabetes Mellitus Type 1. [3]
Nervous System
Excessive activity of 5-Lipoxygenase may be involved in the onset and progression of Alzheimer’s Disease due to its role in the production of inflammatory Series 4 Leukotrienes. [4]
Skin
Excessive production of Lipoxygenase may cause Psoriasis by catalyzing the production of excessive quantities of Series 4 Leukotrienes.
These Substances may Inhibit the Production/Activity of Lipoxygenase
Enzymes
Glutathione Peroxidase may inhibit the production of Lipoxygenase.
Hormones
Melatonin may inhibit the production of Lipoxygenase. [5]
Lipids
Boswellic Acid a constituent of the Herb, Boswellia may inhibit the 5-Lipoxygenase form of Lipoxygenase. [6]
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