Caffeine - Toxic Effects

Toxic Effects of Excessive Caffeine Consumption

 The LD 50 of orally administered Caffeine is estimated at 150 mg per kg of bodyweight - i.e. 10 grams for a person weighing 67 kg.

 Some people (those who are allergic to Caffeine) may experience the toxic effects of Caffeine at doses as low as 250 mg per day. 

Cardiovascular System

 Caffeine may increase the risk of Hypertension (Caffeine increases Blood Pressure).   ^[1]

 Excessive dosages of Caffeine (above 11 mg per kg of bodyweight) may cause temporary Tachycardia.  ^[2]

Digestive System

 Vomiting may occur as a result of acute Caffeine over-dosage.

Exercise

 Caffeine may increase levels of Lactic Acid in the Muscles of people who undertake Endurance Exercise:

 In one human study 6 mg of Caffeine per kg of body weight administered prior to Endurance Exercise resulted in a significant increase in Muscle Lactic Acid levels while exercising.

 However Caffeine also exerts other BENEFICIAL effects on people who undertake Endurance Exercise.

Excretory System

 Excessive Caffeine consumption may irritate the Bladder.

 Excessive Caffeine consumption may irritate the Kidneys.

 Excessive Caffeine consumption may cause Kidney Stones (due to Caffeine increasing urinary Calcium excretion).  ^[3]