Melatonin - Bioavailability
Bioavailability of Exogenous Melatonin [1]
Oral Bioavailability
The absorption of orally-administered Melatonin into the bloodstream varies substantially among different individuals.
First-pass metabolism by the Liver causes the transformation of (varying amounts of) Melatonin to 6-Hydroxy-Melatonin. The efficiency of this transformation varies between individuals - people with an efficient Liver may metabolize up to 95% of ingested Melatonin to 6-Hydroxy-Melatonin.
One study found a 35-fold difference in the amount of serum Melatonin between different individuals after the ingesting a 2 mg dose.
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