Melatonin - Biochemical Testing of Melatonin Status

Introduction

This section aims to assist health care providers in the clinical assessment of Melatonin status in patients.

Plasma/Serum Melatonin

 The standard reference range for Plasma Melatonin varies between laboratories.  The following are representative values:

 0 – 50 pg per mL (day)

 3.30 - 93.2 pg per ml (8AM – females)

 5.63 - 61.8 pg per ml (8 AM – males)

 18.3 - 134 pg per ml (3 AM – males)

 19.0 - 197 pg per ml (3AM – females)

 46 – 150 pg per mL (night)

Salivary Melatonin

 The standard reference range for Salivary Melatonin varies between laboratories.  The following are representative values:

 3.5 – 33.0 pmol per liter (morning)

 0.0 – 11.9 pmol per liter (evening)

 16.0 – 100.0 pmol per liter (midnight)

 Melatonin