Melatonin - Contraindications and Toxic Effects

Introduction

This section describes situations in which Melatonin supplementation is contraindicated;  and the situations in which Melatonin supplementation may produce toxicity or side effects.

There have been no serious side effects reported for Melatonin supplementation.  ^[1]

Age Factors

 People under the age 40-45 should not use Melatonin supplements on a daily basis for Life Extension purposes:

 This aspect of Melatonin is based on a study in which young mice supplemented chronically with Melatonin experienced shortened life spans.

Immune System

 People who are afflicted with Autoimmune Diseases such as Systemic Lupus Erythematosus (SLE) are advised to avoid supplemental Melatonin (due to Melatonin's ability to further stimulate the already over-stimulated Immune System that occurs with Autoimmune Diseases).  ^[2]

Nervous System

 Melatonin may cause Depression in approximately 2% of persons using supplemental Melatonin.

 Although supplemental Melatonin often improves the quality/vividness of Dreaming, 5% of persons report bad Dreams and Nightmares:  ^[3]