Saquinavir
Description
Saquinavir is a type of HIV Protease Inhibitor Pharmaceutical Drug.
Conventional Medical Use of Saquinavir
Immune System
Saquinavir is prescribed for the treatment of Acquired Immune Deficiency Syndrome (AIDS) - it inhibits the replication of the HIV virus by inhibiting HIV Protease (a component of the HIV virus).
Potentially Toxic Effects of Saquinavir
Digestive System
Saquinavir may cause Diarrhea.
Nervous System
Saquinavir may cause Nausea.
These Substances Increase the Bioavailability of Saquinavir
Prescribed Medications
Ranitidine increases the bioavailability (and therefore potency and effectiveness) of Saquinavir.
These Foods may Increase the Bioavailability of Saquinavir
Fruit
When Saquinavir is consumed in conjunction with Grapefruit (especially Grapefruit Juice), its potency increases significantly (by up to 220%).
Bioavailability
Normally the oral bioavailability of Saquinavir is poor.
Dosage Recommendations
The recommended dosage of Saquinavir for the treatment of AIDS is 2,000 mg per day (taken as 2 x 1,000 mg doses).
Saquinavir is only used in combination with Ritonavir (200 mg per day) and in combination with other Antiretroviral drugs.
Commercial Availability of Saquinavir
Oral Products
Saquinavir is available from pharmacies (prescription required) in the form of:
500 mg tablets (Invirase)
Chemical Data
Chemical Formula
C38H50N6O51:1CH4O3S
Molecular Weight
766.96
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