PEGylated Liposomes

1 min readEvidence-linked topicGreen Medicine Encyclopedia

Description

PEGylated Liposomes are a form of Liposomes.  They are Liposomes that have been subjected to the process of PEGylation.

 

PEGylation involves the formation of a polymer (long-chain molecule) consisting of repeating units of Ethylene Glycol.  The resulting polymer is a colorless liquid named Polyethylene Glycol (PEG).  PEG is water-soluble and is also soluble in many organic solvents.

 

Uses for PEGylated Liposomes

 PEGylated Liposomes form biologically inactive molecular “shields” that encase various drugs/nutrients, thereby increasing the drug or nutrient’s bioavailability, absorption, distribution and metabolism.  This occurs because PEGylated Liposomes are not detected as Antibodies by Phagocytes (one type of White Blood Cell in the Immune System) .  The drug or nutrient remains inert until the PEGylated Liposome breaks down and “spills” its contents.  [1]

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